Structure of PDB 1j1u Chain A

Receptor sequence
>1j1uA (length=299) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MDEFEMIKRNTSEIISEEELREVLKKDEKSAYIGFEPSGKIHLGHYLQIK
KMIDLQNAGFDIIILLADLHAYLNQKGELDEIRKIGDYNKKVFEAMGLKA
KYVYGSEFQLDKDYTLNVYRLALKTTLKRARRSMELIAREDENPKVAEVI
YPIMQVNDIHYLGVDVAVGGMEQRKIHMLARELLPKKVVCIHNPVLTGLD
GEGNFIAVDDSPEEIRAKIKKAYCPAGVVEGNPIMEIAKYFLEYPLTIKR
PEKFGGDLTVNSYEELESLFKNKELHPMDLKNAVAEELIKILEPIRKRL
3D structure
PDB1j1u Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N143 K227 K228 A229 Y230 C231 P232 F261 H283 P284 M285 D286 K288 N143 K220 K221 A222 Y223 C224 P225 F254 H276 P277 M278 D279 K281
BS02 TYR A Y32 G34 L65 H70 Y151 Q155 D158 Q173 Y32 G34 L65 H70 Y151 Q155 D158 Q173
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1j1u, PDBe:1j1u, PDBj:1j1u
PDBsum1j1u
PubMed12754495
UniProtQ57834|SYY_METJA Tyrosine--tRNA ligase (Gene Name=tyrS)

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