Structure of PDB 1iv2 Chain A

Receptor sequence
>1iv2A (length=150) Species: 274 (Thermus thermophilus) [Search protein sequence]
RIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAAMHALTDALLSA
YGLGDIGLLFPDTDPRWRGERSEVFLREAMRLVEARGAKLLQASLVLTLD
RPKLGPHRKALVDSLSRLMRLPQDRIGLTFKTSEGLAPSHVQARAVVLLD
3D structure
PDB1iv2 Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D8 H10 H42 D7 H9 H41
BS02 CDP A H10 D56 G58 H9 D55 G57
BS03 CDP A L100 K104 L105 G106 F131 K132 T133 E135 L99 K103 L104 G105 F130 K131 T132 E134
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1iv2, PDBe:1iv2, PDBj:1iv2
PDBsum1iv2
PubMed12499535
UniProtQ8RQP5|ISPF_THET8 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF)

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