Structure of PDB 1itw Chain A

Receptor sequence
>1itwA (length=740) Species: 354 (Azotobacter vinelandii) [Search protein sequence]
STPKIIYTLTDEAPALATYSLLPIIKAFTGSSGIAVETRDISLAGRLIAT
FPEYLTDTQKISDDLAELGKLATTPDANIIKLPNISASVPQLKAAIKELQ
QQGYKLPDYPEEPKTDTEKDVKARYDKIKGSAVNPVLREGNSDRRAPLSV
KNYARKHPHKMGAWSADSKSHVAHMDNGDFYGSEKAALIGAPGSVKIELI
AKDGSSTVLKAKTSVQAGEIIDSSVMSKNALRNFIAAEIEDAKKQGVLLS
VHLKATMMKVSDPIMFGQIVSEFYKDALTKHAEVLKQIGFDVNNGIGDLY
ARIKTLPEAKQKEIEADIQAVYAQRPQLAMVNSDKGITNLHVPSDVIVDA
SMPAMIRDSGKMWGPDGKLHDTKAVIPDRCYAGVYQVVIEDCKQHGAFDP
TTMGSVPNVGLMAQKAEEYGSHDKTFQIPADGVVRVTDESGKLLLEQSVE
AGDIWRMCQAKDAPIQDWVKLAVNRARATNTPAVFWLDPARAHDAQVIAK
VERYLKDYDTSGLDIRILSPVEATRFSLARIREGKDTISVTGNVLRDYLT
DLFPIMELGTSAKMLSIVPLMSGGGLFETGAGGSAPKHVQQFLEEGYLRW
DSLGEFLALAASLEHLGNAYKNPKALVLASTLDQATGKILDNNKSPARKV
GEIDNRGSHFYLALYWAQALAAQTEDKELQAQFTGIAKALTDNETKIVGE
LAAAQGKPVDIAGYYHPNTDLTSKAMRPSATFNAALAPLA
3D structure
PDB1itw Structure of the Monomeric Isocitrate Dehydrogenase: Evidence of a Protein Monomerization by a Domain Duplication
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D350 D548 D349 D547
Gene Ontology
Molecular Function
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1itw, PDBe:1itw, PDBj:1itw
PDBsum1itw
PubMed12467571
UniProtP16100|IDH_AZOVI Isocitrate dehydrogenase [NADP] (Gene Name=icd)

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