Structure of PDB 1iqu Chain A

Receptor sequence
>1iquA (length=415) Species: 274 (Thermus thermophilus) [Search protein sequence]
GPLLVWHRGDLRLHDHPALLEALARGPVVGLVVLDPNNLKTTPRRRAWFL
ENVRALREAYRARGGALWVLEGLPWEKVPEAARRLKAKAVYALTSHTPYG
RYRDGRVREALPVPLHLLPAPHLLPPDLPRAYRVYTPFSRLYRGAAPPLP
PPEALPKGPEEGEIPREDPGLPLPEPGEEAALAGLRAFLEAKLPRYAEER
DRLDGEGGSRLSPYFALGVLSPRLAAWEAERRGGEGARKWVAELLWRDFS
YHLLYHFPWMAERPLDPRFQAFPWQEDEALFQAWYEGKTGVPLVDAAMRE
LHATGFLSNRARMNAAQFAVKHLLLPWKRCEEAFRHLLLDGDRAVNLQGW
QWAGGLGVDAAPYFRVFNPVLQGERHDPEGRWLKRWAPEYPSYAPKDPVV
DLEEARRRYLRLARD
3D structure
PDB1iqu Crystal structure of thermostable DNA photolyase: pyrimidine-dimer recognition mechanism.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E244 W247 W275 N310 W328 W351
Catalytic site (residue number reindexed from 1) E243 W246 W274 N309 W327 W350
Enzyme Commision number 4.1.99.3: deoxyribodipyrimidine photo-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TDR A W247 N310 M314 Q349 W353 W246 N309 M313 Q348 W352
BS02 FAD A Y197 S210 R211 S213 F216 W241 E244 W247 R248 N310 R313 M314 D341 D343 V346 N347 G350 Y196 S209 R210 S212 F215 W240 E243 W246 R247 N309 R312 M313 D340 D342 V345 N346 G349
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003904 deoxyribodipyrimidine photo-lyase activity
GO:0016829 lyase activity
GO:0071949 FAD binding
GO:0097159 organic cyclic compound binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0006950 response to stress
GO:0009416 response to light stimulus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1iqu, PDBe:1iqu, PDBj:1iqu
PDBsum1iqu
PubMed11707580
UniProtP61497|PHR_THET8 Deoxyribodipyrimidine photo-lyase (Gene Name=phr)

[Back to BioLiP]