Structure of PDB 1ilq Chain A
Receptor sequence
>1ilqA (length=71) Species:
9606
(Homo sapiens) [
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AKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCL
DPKENWVQRVVEKFLKRAENS
3D structure
PDB
1ilq
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.
Chain
A
Resolution
N/A
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
peptide
A
Q8 I10 K11 Y13 H18 K20 F21 I40 L43 S44 D45 R47 E48 L49
Q7 I9 K10 Y12 H17 K19 F20 I39 L42 S43 D44 R46 E47 L48
Gene Ontology
Molecular Function
GO:0005125
cytokine activity
GO:0005153
interleukin-8 receptor binding
GO:0005515
protein binding
GO:0008009
chemokine activity
GO:0008201
heparin binding
GO:0045236
CXCR chemokine receptor binding
Biological Process
GO:0001525
angiogenesis
GO:0002237
response to molecule of bacterial origin
GO:0006935
chemotaxis
GO:0006952
defense response
GO:0006954
inflammatory response
GO:0006955
immune response
GO:0007165
signal transduction
GO:0007186
G protein-coupled receptor signaling pathway
GO:0008285
negative regulation of cell population proliferation
GO:0010628
positive regulation of gene expression
GO:0010629
negative regulation of gene expression
GO:0019722
calcium-mediated signaling
GO:0030155
regulation of cell adhesion
GO:0030593
neutrophil chemotaxis
GO:0031328
positive regulation of cellular biosynthetic process
GO:0031623
receptor internalization
GO:0034976
response to endoplasmic reticulum stress
GO:0035556
intracellular signal transduction
GO:0042119
neutrophil activation
GO:0044344
cellular response to fibroblast growth factor stimulus
GO:0045091
regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045744
negative regulation of G protein-coupled receptor signaling pathway
GO:0045766
positive regulation of angiogenesis
GO:0048566
embryonic digestive tract development
GO:0050930
induction of positive chemotaxis
GO:0060354
negative regulation of cell adhesion molecule production
GO:0061844
antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098
chemokine-mediated signaling pathway
GO:0071222
cellular response to lipopolysaccharide
GO:0071347
cellular response to interleukin-1
GO:0071356
cellular response to tumor necrosis factor
GO:0090023
positive regulation of neutrophil chemotaxis
GO:2000535
regulation of entry of bacterium into host cell
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1ilq
,
PDBe:1ilq
,
PDBj:1ilq
PDBsum
1ilq
PubMed
10368283
UniProt
P10145
|IL8_HUMAN Interleukin-8 (Gene Name=CXCL8)
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