Structure of PDB 1ilh Chain A

Receptor sequence
>1ilhA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVKWSQVRKDLCSLKV
SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI
SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDT
AGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRV
VDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL
LRIQDIHPFATPLMQELFGI
3D structure
PDB1ilh The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
ChainA
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRL A M243 M246 S247 F251 F281 C284 Q285 F288 W299 M82 M85 S86 F90 F120 C123 Q124 F127 W138 PDBbind-CN: -logKd/Ki=7.39,Kd=41nM
BindingDB: EC50=440nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1ilh, PDBe:1ilh, PDBj:1ilh
PDBsum1ilh
PubMed11408620
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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