Structure of PDB 1il9 Chain A

Receptor sequence
>1il9A (length=267) Species: 3988 (Ricinus communis) [Search protein sequence]
IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVG
LPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQED
AEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISA
LYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAP
DPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIP
IIALMVYRCAPPPSSQF
3D structure
PDB1il9 Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V81 E177 R180
Catalytic site (residue number reindexed from 1) V81 E177 R180
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MOG A A79 Y80 V81 F93 G121 N122 Y123 I172 R180 A79 Y80 V81 F93 G121 N122 Y123 I172 R180 PDBbind-CN: -logKd/Ki=3.40,IC50=0.40mM
BindingDB: IC50=400000nM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:1il9, PDBe:1il9, PDBj:1il9
PDBsum1il9
PubMed11754581
UniProtP02879|RICI_RICCO Ricin

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