Structure of PDB 1il0 Chain A

Receptor sequence

>1il0A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]

KIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEES
LRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVEN
LKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFN
PVPVMKLVQVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLL
VPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFI
VDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK

3D structure

PDB

1il0 Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S137 H158 Q170 N208
Catalytic site (residue number reindexed from 1)	S126 H147 Q159 N197
Enzyme Commision number	1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CAA	A	S61 K68 S137 H158 F160 N161 V165 N208 P243 M244 L249 V253	S50 K57 S126 H147 F149 N150 V154 N197 P232 M233 L238 V242
BS02	NAD	A	G24 L25 M26 D45 Q46 A107 I108 E110 K115 N135 S137 N161 V253 T257 K293	G13 L14 M15 D34 Q35 A96 I97 E99 K104 N124 S126 N150 V242 T246 K282
BS03	CAA	A	G239 A240	G228 A229

Gene Ontology

	Molecular Function
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016740	transferase activity
GO:0042802	identical protein binding
GO:0070403	NAD+ binding

	Biological Process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0007283	spermatogenesis
GO:0009410	response to xenobiotic stimulus
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0030154	cell differentiation
GO:0032868	response to insulin
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0120162	positive regulation of cold-induced thermogenesis

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1il0, PDBe:1il0, PDBj:1il0
PDBsum	1il0
PubMed	11451959
UniProt	Q16836\|HCDH_HUMAN Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (Gene Name=HADH)

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