Structure of PDB 1ikt Chain A

Receptor sequence
>1iktA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
LQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSG
SGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIM
LSQKLQMILKDYAKL
3D structure
PDB1ikt Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 A resolution.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase.
4.2.1.107: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase.
4.2.1.119: enoyl-CoA hydratase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OXN A W36 F79 Q90 F93 S107 Q108 Q111 W31 F74 Q85 F88 S102 Q103 Q106 PDBbind-CN: -logKd/Ki=3.40,Kd=400uM
External links
PDB RCSB:1ikt, PDBe:1ikt, PDBj:1ikt
PDBsum1ikt
PubMed11700068
UniProtP51659|DHB4_HUMAN Peroxisomal multifunctional enzyme type 2 (Gene Name=HSD17B4)

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