Structure of PDB 1ijr Chain A

Receptor sequence
>1ijrA (length=104) Species: 9606 (Homo sapiens) [Search protein sequence]
APEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFCLSVRDFDQ
NQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSR
PCQT
3D structure
PDB1ijr A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CC0 A R12 R32 S34 E35 S36 C42 H58 Y59 K60 I71 G93 R12 R32 S34 E35 S36 C42 H58 Y59 K60 I71 G93 PDBbind-CN: -logKd/Ki=5.44,IC50=3.6uM
External links
PDB RCSB:1ijr, PDBe:1ijr, PDBj:1ijr
PDBsum1ijr
PubMed11527723
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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