Structure of PDB 1igz Chain A

Receptor sequence

>1igzA (length=553) Species: 9940 (Ovis aries) [Search protein sequence]

PVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTT
LRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYN
IAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLG
HIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPP
QSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQT
ARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEF
NQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPA
GRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQEL
TGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSL
KGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFH
VPD

3D structure

PDB

1igz Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.

Chain

Resolution

2.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q203 H207 L384 Y385 H388 G526 S530
Catalytic site (residue number reindexed from 1)	Q172 H176 L353 Y354 H357 G495 S499
Enzyme Commision number	1.14.99.1: prostaglandin-endoperoxide synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	BGC	A	S87 F88 F91	S56 F57 F60
BS02	COH	A	Q203 H207 F210 T212 L295 H386 W387 H388 M391 I444 V447 D450	Q172 H176 F179 T181 L264 H355 W356 H357 M360 I413 V416 D419
BS03	EIC	A	R120 F205 F209 Y348 L352 Y355 F381 Y385 W387 I523 A527 S530	R89 F174 F178 Y317 L321 Y324 F350 Y354 W356 I492 A496 S499

Gene Ontology

	Molecular Function
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

	Biological Process
GO:0001516	prostaglandin biosynthetic process
GO:0006979	response to oxidative stress
GO:0008217	regulation of blood pressure
GO:0019371	cyclooxygenase pathway
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1igz, PDBe:1igz, PDBj:1igz
PDBsum	1igz
PubMed	11477109
UniProt	P05979\|PGH1_SHEEP Prostaglandin G/H synthase 1 (Gene Name=PTGS1)

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