Structure of PDB 1ie9 Chain A

Receptor sequence
>1ie9A (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
DSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSVT
LELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAI
EVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV
GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIR
CRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLV
LEVFG
3D structure
PDB1ie9 Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VDX A Y143 L233 S237 R274 S275 S278 W286 H305 H397 Y26 L65 S69 R106 S107 S110 W118 H137 H229 PDBbind-CN: -logKd/Ki=10.19,Kd=0.065nM
BindingDB: EC50=10nM,IC50=1.1nM,Kd=0.065nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1ie9, PDBe:1ie9, PDBj:1ie9
PDBsum1ie9
PubMed11344298
UniProtP11473|VDR_HUMAN Vitamin D3 receptor (Gene Name=VDR)

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