Structure of PDB 1ic8 Chain A

Receptor sequence
>1ic8A (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
KELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDT
TGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHARNRFKW
GPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGS
NLVTEVRVYNWFANRRKEEA
3D structure
PDB1ic8 Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P129 Q130 R131 Q141 S145 Q146 R203 P224 Y265 K273 P43 Q44 R45 Q55 S59 Q60 R97 P118 Y159 K167
BS02 dna A N140 S142 H143 P153 M154 K155 K158 F204 K205 W206 R263 N270 N54 S56 H57 P67 M68 K69 K72 F98 K99 W100 R157 N164
Gene Ontology
Biological Process
GO:0001889 liver development
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030073 insulin secretion
GO:0031016 pancreas development
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1ic8, PDBe:1ic8, PDBj:1ic8
PDBsum1ic8
PubMed12453420
UniProtP20823|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)

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