Structure of PDB 1ia9 Chain A

Receptor sequence
>1ia9A (length=276) Species: 10090 (Mus musculus) [Search protein sequence]
YYYSAVERNNLMRLSQSIPFVPVPPRGEPVTVYRLEESSPSILNNSMSSW
SQLGLCAKIEFLSKMGGGLRRAVKVLCTWSEHDILKSGHLYIIKSFLPEV
INTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLE
VFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHW
TYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIK
NFRAKHHCNSCCRKLKLPDLKRNDYT
3D structure
PDB1ia9 Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H1751 H1808 C1810 C1814 H199 H256 C258 C262
BS02 ANP A M1617 G1619 G1620 R1622 K1646 E1718 M1721 F1725 Q1767 D1775 M65 G67 G68 R70 K94 E166 M169 F173 Q215 D223
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ia9, PDBe:1ia9, PDBj:1ia9
PDBsum1ia9
PubMed11389851
UniProtQ923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (Gene Name=Trpm7)

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