Structure of PDB 1i8q Chain A

Receptor sequence
>1i8qA (length=814) Species: 1311 (Streptococcus agalactiae) [Search protein sequence]
SEHPQPVTTQIEKSVNTALNKNYVFNKADYQYTLTNPSLGKIVGGILYPN
ATGSTTVKISDKSGKIIKEVPLSVTASTEDNFTKLLDKWNDVTIGNYVYD
TNDSNMQKLNQKLDETNAKNIEAIKLDSNRTFLWKDLDNLNNSAQLTATY
RRLEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYNVNKDIEGSAN
WWDFEIGVPRSITGTLSLMNNYFTDAEIKTYTDPIEHFVPDAEYFRKTLV
NPFKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAEGF
YADGSYIDHTNVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYK
WINQSFLPLIVKGELMDMSRGRSISREAASSHAAAVEVLRGFLRLANMSN
EERNLDLKSTIKTIITSNKFYNVFNNLKSYSDIANMNKLLNDSTVATKPL
KSNLSTFNSMDRLAYYNAKKDFGFALSLHSKRTLNYEGMNDENTRGWYTG
DGMFYIYNSDQSHYSNHFWPTVNPYKMAGTTEKDAKREDTTKEFMSKHSK
DAKEKTGQVTGTSDFVGSVKLNDHFALAAMDFTNWDRTLTAQKGWVILND
KIVFLGSNIKNTNGIGNVSTTIDQRKDDSKTPYTTYVNGKTIDLKQASSQ
QFTDTKSVFLESKEPGRNIGYIFFKNSTIDIERKEQTGTWNSINRTSKNT
SIVSNPFITISQKHDNKGDSYGYMMVPNIDRTSFDKLANSKEVELLENSS
KQQVIYDKNSQTWAVIKHDNQESLINNQFKMNKAGLYLVQKVGNDYQNVY
YQPQTMTKTDQLAI
3D structure
PDB1i8q Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N429 H479 Y488 R542 E657
Catalytic site (residue number reindexed from 1) N259 H309 Y318 R372 E487
Enzyme Commision number 4.2.2.1: hyaluronate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GC4 A R321 W372 D432 R151 W202 D262
BS02 GC4 A N370 W371 R416 N200 W201 R246
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1i8q, PDBe:1i8q, PDBj:1i8q
PDBsum1i8q
PubMed11527972
UniProtQ53591|HYSA_STRA3 Hyaluronate lyase (Gene Name=hylB)

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