Structure of PDB 1i7g Chain A

Receptor sequence
>1i7gA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGSNNPPFVIHDMETLCMA
EKTLQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL
KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLR
LHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPL
LQEIYRDMY
3D structure
PDB1i7g Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZ2 A F273 C275 C276 S280 Y314 M330 V332 H440 Y464 F64 C66 C67 S71 Y105 M121 V123 H231 Y255 MOAD: ic50=1uM
PDBbind-CN: -logKd/Ki=6.00,IC50=1.0uM
BindingDB: EC50=820nM,Ki=1000nM
BS02 CPQ A K204 K208 L410 H411 K6 K10 L201 H202
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1i7g, PDBe:1i7g, PDBj:1i7g
PDBsum1i7g
PubMed11587644
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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