Structure of PDB 1i4o Chain A

Receptor sequence
>1i4oA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSL
GFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKD
GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQYKIPVEAD
FLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDR
VARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
3D structure
PDB1i4o Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G31 V32 H90 G91 C132
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G83 M84 G85 H144 Y230 W232 R233 W240 S275 Q276 S277 F282 G29 M30 G31 H90 Y162 W164 R165 W172 S207 Q208 S209 F214
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0009411 response to UV
GO:0016485 protein processing
GO:0030163 protein catabolic process
GO:0042742 defense response to bacterium
GO:0043525 positive regulation of neuron apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0051146 striated muscle cell differentiation
GO:0051402 neuron apoptotic process
GO:0051604 protein maturation
GO:0070227 lymphocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071887 leukocyte apoptotic process
GO:0072734 cellular response to staurosporine
GO:0097194 execution phase of apoptosis
GO:1905686 positive regulation of plasma membrane repair
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1i4o, PDBe:1i4o, PDBj:1i4o
PDBsum1i4o
PubMed11257231
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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