Structure of PDB 1i44 Chain A

Receptor sequence
>1i44A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNES
ASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLK
SYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAA
RNCMVAHDFTVKIGDFGMTLPVRWMAPESLKDGVFTTSSDMWSFGVVLWE
ITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPK
MRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
3D structure
PDB1i44 Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1132 A1134 R1136 N1137 D1150 L1171
Catalytic site (residue number reindexed from 1) D147 A149 R151 N152 D165 L170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A L1002 Q1004 G1005 S1006 A1028 K1030 M1079 M1139 L17 Q19 G20 S21 A43 K45 M94 M154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1i44, PDBe:1i44, PDBj:1i44
PDBsum1i44
PubMed11124964
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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