Structure of PDB 1i37 Chain A

Receptor sequence
>1i37A (length=246) Species: 10116 (Rattus norvegicus) [Search protein sequence]
IFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKA
LPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFN
EYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGL
KNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIAR
ELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB1i37 Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 L707 Q711 M745 M749 F764 M780 T877 M895 L33 N34 L36 Q40 M74 M78 F93 M109 T206 M224 PDBbind-CN: -logKd/Ki=9.57,Ki=0.27nM
BindingDB: IC50=3.1nM,EC50=0.97nM,Ki=0.43nM
External links
PDB RCSB:1i37, PDBe:1i37, PDBj:1i37
PDBsum1i37
PubMed11320241
UniProtP15207|ANDR_RAT Androgen receptor (Gene Name=Ar)

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