Structure of PDB 1i22 Chain A

Receptor sequence
>1i22A (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDR
STDYGIFQINSRYWCNDGKTPGAVNACHLSCSKLLDDNIADDVACAKRVV
RDPQGIRAWVAWRNRCQNRDVRQYVQGCGV
3D structure
PDB1i22 Structural and thermodynamic responses of mutations at a Ca2+ binding site engineered into human lysozyme.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E35 N46 D49 S51 D53 N60
Catalytic site (residue number reindexed from 1) E35 N46 D49 S51 D53 N60
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K83 D86 N88 D91 D92 K83 D86 N88 D91 D92
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
Biological Process
GO:0006954 inflammatory response
GO:0019730 antimicrobial humoral response
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen

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Cellular Component
External links
PDB RCSB:1i22, PDBe:1i22, PDBj:1i22
PDBsum1i22
PubMed9852096
UniProtP61626|LYSC_HUMAN Lysozyme C (Gene Name=LYZ)

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