Structure of PDB 1i19 Chain A

Receptor sequence
>1i19A (length=541) Species: 1702 (Brevibacterium sterolicum) [Search protein sequence]
VAPLPTPPNFPNDIALFQQAYQNWSKEIMLDATWVCSPKTPQDVVRLANW
AHEHDYKIRPRGAMHGWTPLTVEKGANVEKVILADTMTHLNGITVNTGGP
VATVTAGAGASIEAIVTELQKHDLGWANLPAPGVLSIGGALAVNAHGAAL
PAVGQTTLPGHTYGSLSNLVTELTAVVWNGTTYALETYQRNDPRITPLLT
NLGRCFLTSVTMQAGPNFRQRCQSYTDIPWRELFAPKGADGRTFEKFVAE
SGGAEAIWYPFTEKPWMKVWTVSPSLVGKPPQAREVSGPYNYIFSDNLPE
PITDMIGAINAGNPGIAPLFGPAMYEITKLGLAATNANDIWGWSKDVQFY
IKATTLRLTEGGGAVVTSRANIATVINDFTEWFHERIEFYRAKGEFPLNG
PVEIRCCGLDQAADVKVPSVGPPTISATRPRPDHPDWDVAIWLNVLGVPG
TPGMFEFYREMEQWMRSHYNNDDATFRPEWSKGWAFGPDPYTDNDIVTNK
MRATYIEGVPTTENWDTARARYNQIDPHRVFTNGFMDKLLP
3D structure
PDB1i19 Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H121 E311 E475 R477
Catalytic site (residue number reindexed from 1) H65 E255 E403 R405
Enzyme Commision number 1.1.3.6: cholesterol oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A W80 P116 G118 A119 M120 H121 G122 W123 L126 P186 A187 P188 L191 S192 G194 G195 A198 V199 A201 H202 L258 G259 L263 S553 W24 P60 G62 A63 M64 H65 G66 W67 L70 P130 A131 P132 L135 S136 G138 G139 A142 V143 A145 H146 L202 G203 L207 S481
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding

View graph for
Molecular Function
External links
PDB RCSB:1i19, PDBe:1i19, PDBj:1i19
PDBsum1i19
PubMed11397813
UniProtQ7SID9

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