Structure of PDB 1hyv Chain A

Receptor sequence
>1hyvA (length=144) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGQGVIESMNKELKKIIG
QVRDQAEHLKTAVQMAVFIHNKKRKGGYSAGERIVDIIATDIQT
3D structure
PDB1hyv Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTA A D167 Q168 A169 T174 D104 Q105 A106 T111 MOAD: ic50>5mM
PDBbind-CN: -logKd/Ki=2.30,IC50>5mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:1hyv, PDBe:1hyv, PDBj:1hyv
PDBsum1hyv
PubMed11264582
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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