Structure of PDB 1hyb Chain A

Receptor sequence
>1hybA (length=161) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence]
MRGLLVGRMQPFHRGALQVIKSILEEVDELIICIGSAQLSHSIRDPFTAG
ERVMMLTKALSENGIPASRYYIIPVQDIECNALWVGHIKMLTPPFDRVYS
GNPLVQRLFSEDGYEVTAPPYSGTEVRRRMLDDGDWRSLLPESVVEVIDE
INGVERIKHLA
3D structure
PDB1hyb Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.1: nicotinamide-nucleotide adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R11 G132 T133 R136 R8 G123 T124 R127
BS02 NMN A V9 R11 G38 S39 D80 I81 N84 W87 L107 V6 R8 G35 S36 D77 I78 N81 W84 L104
Gene Ontology
Molecular Function
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:1hyb, PDBe:1hyb, PDBj:1hyb
PDBsum1hyb
PubMed11063748
UniProtO26253|NADM_METTH Nicotinamide-nucleotide adenylyltransferase (Gene Name=MTH_150)

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