Structure of PDB 1hxq Chain A

Receptor sequence
>1hxqA (length=340) Species: 562 (Escherichia coli) [Search protein sequence]
TQFNPVDHPHRRYNPLTGQWILVSPHRAKRPWQGAVLPAHDPDCFLCAGN
VRVTGDKNPDYTGTYVFTNDFAALMSDTPDAPESHDPLMRCQSARGTSRV
ICFSPDHSKTLPELSVAALTEIVKTWQEQTAELGKTYPWVQVFENKGAAM
GCSNPHPHGQIWANSFLPNEAEREDRLQKEYFAEQKSPMLVDYVQRELAD
GSRTVVETEHWLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRSDLALA
LKKLTSRYDNLFQCSFPYSMGWHGAPFNGEENQHWQLHAHFYPPLLRSAT
VRKFMVGYEMLAETQRDLTAEQAAERLRAVSDIHFRESGV
3D structure
PDB1hxq The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer.
ChainA
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C52 C55 H115 N153 S161 H164 H166 Q168
Catalytic site (residue number reindexed from 1) C44 C47 H107 N145 S153 H156 H158 Q160
Enzyme Commision number 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C52 C55 H115 H164 C44 C47 H107 H156
BS02 FE A E182 H281 H296 H298 E174 H273 H288 H290
BS03 U5P A V61 N77 D78 F79 V108 C160 H166 Q168 V53 N69 D70 F71 V100 C152 H158 Q160
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006012 galactose metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hxq, PDBe:1hxq, PDBj:1hxq
PDBsum1hxq
PubMed8794735
UniProtP09148|GAL7_ECOLI Galactose-1-phosphate uridylyltransferase (Gene Name=galT)

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