Structure of PDB 1hxc Chain A

Receptor sequence
>1hxcA (length=516) Species: 4097 (Nicotiana tabacum) [Search protein sequence]
SPSLWGDQFLSFSIDNQVAEKYAKEIEALKEQTRNMLLATGMKLADTLNL
IDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLLRQHGFN
ISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDILEDALAF
STIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSIYDKEQS
KNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYARDRVVEC
YFWALGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELEAYTDAI
QRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCHAIERMK
EVVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYYLATTSYLGMKSATE
QDFEWLSKNPKILEASVIIWRVIDDTATYEVEKSRGQIATGIECCMRDYG
ISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLARIVEVTY
VLKPHIINLLVDSIKI
3D structure
PDB1hxc Single Active Site Mutations Change the Specificity of a Sesquiterpene Cyclase
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R264 W273 I294 D301 D305 T401 T402 T403 R441 D444 T448 E452 Y520
Catalytic site (residue number reindexed from 1) R244 W253 I274 D281 D285 T381 T382 T383 R421 D424 T428 E432 Y500
Enzyme Commision number 4.2.3.61: 5-epiaristolochene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FHP A I294 D301 Y376 E379 T401 T402 W440 I274 D281 Y356 E359 T381 T382 W420
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
GO:0016838 carbon-oxygen lyase activity, acting on phosphates
GO:0046872 metal ion binding
GO:0102698 5-epi-aristolochene synthase activity
Biological Process
GO:0006720 isoprenoid metabolic process
GO:0016102 diterpenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0051762 sesquiterpene biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:1hxc, PDBe:1hxc, PDBj:1hxc
PDBsum1hxc
PubMed
UniProtQ40577|5EAS_TOBAC 5-epi-aristolochene synthase (Gene Name=EAS3)

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