Structure of PDB 1hw5 Chain A

Receptor sequence
>1hw5A (length=208) Species: 562 (Escherichia coli) [Search protein sequence]
VLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVL
IKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYK
KFRQLIQVNPDILMRLSAQMARRLQVLAEKVGNLAFLDVTGRIAQTLLNL
AKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHG
KTIVVYGT
3D structure
PDB1hw5 The structure of the T127L/S128A mutant of cAMP receptor protein facilitates promoter site binding
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A S62 I70 G71 E72 L73 R82 S83 R123 L127 S62 I70 G71 E72 L73 R82 S83 R123 L127 Manual survey: Kb=2.0+-0.3M^-1 (11124966)
BS02 CMP A K57 E58 Q170 Q174 G177 C178 S179 R180 K57 E58 Q170 Q174 G177 C178 S179 R180 Manual survey: Kb=2.0+-0.3M^-1 (11124966)
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0045013 carbon catabolite repression of transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hw5, PDBe:1hw5, PDBj:1hw5
PDBsum1hw5
PubMed11124966
UniProtP0ACJ8|CRP_ECOLI DNA-binding transcriptional dual regulator CRP (Gene Name=crp)

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