Structure of PDB 1hw2 Chain A

Receptor sequence
>1hw2A (length=222) Species: 562 (Escherichia coli) [Search protein sequence]
SPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLA
RDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRT
NISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFAS
GNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHD
QVYETVRRYGHESGEIWHRMQK
3D structure
PDB1hw2 The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P8 A9 T44 T46 T47 H65 G66 P2 A3 T38 T40 T41 H59 G60
BS02 dna A A33 E34 R35 R45 R49 I63 H65 G66 A27 E28 R29 R39 R43 I57 H59 G60
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006631 fatty acid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hw2, PDBe:1hw2, PDBj:1hw2
PDBsum1hw2
PubMed11279025
UniProtP0A8V6|FADR_ECOLI Fatty acid metabolism regulator protein (Gene Name=fadR)

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