Structure of PDB 1hv9 Chain A

Receptor sequence
>1hv9A (length=449) Species: 562 (Escherichia coli) [Search protein sequence]
NAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHL
VYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLY
GDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIV
EHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIA
LAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVM
LRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVI
GDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKA
RLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFV
GSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRP
3D structure
PDB1hv9 Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R18
Catalytic site (residue number reindexed from 1) R15
Enzyme Commision number 2.3.1.157: glucosamine-1-phosphate N-acetyltransferase.
2.7.7.23: UDP-N-acetylglucosamine diphosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A S405 A422 A423 R440 S402 A419 A420 R437
BS02 UD1 A L11 A13 G14 Q76 Q79 G81 T82 Y103 D105 G140 E154 N169 Y197 L8 A10 G11 Q73 Q76 G78 T79 Y100 D102 G137 E151 N166 Y194
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016779 nucleotidyltransferase activity
GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0008360 regulation of cell shape
GO:0009245 lipid A biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hv9, PDBe:1hv9, PDBj:1hv9
PDBsum1hv9
PubMed11329257
UniProtP0ACC7|GLMU_ECOLI Bifunctional protein GlmU (Gene Name=glmU)

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