Structure of PDB 1hux Chain A

Receptor sequence
>1huxA (length=259) Species: 905 (Acidaminococcus fermentans) [Search protein sequence]
SIYTLGIDVGSTASKCIILKDGKEIVAKSLVAVGTGTSGPARSISEVLEN
AHMKKEDMAFTLATGYGRNSLEGIADKQMSELSCHAMGASFIWPNVHTVI
DIGGQDVKVIHVENGTMTNFQMNDKCAAGTGRFLDVMANILEVKVSDLAE
LGAKSTKRVAISSTCTVFAESEVISQLSKGTDKIDIIAGIHRSVASRVIG
LANRVGIVKDVVMTGGVAQNYGVRGALEEGLGVEIKTSPLAQYNGALGAA
LYAYKKAAK
3D structure
PDB1hux Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A C127 A128 C166 T167 C126 A127 C165 T166
BS02 ADP A G11 S12 T13 K16 S147 G217 V218 Q220 Q243 G10 S11 T12 K15 S146 G216 V217 Q219 Q242
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0019552 glutamate catabolic process via 2-hydroxyglutarate

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1hux, PDBe:1hux, PDBj:1hux
PDBsum1hux
PubMed11243821
UniProtP11568|HGDC_ACIFV (R)-2-hydroxyglutaryl-CoA dehydratase activating ATPase (Gene Name=hgdC)

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