Structure of PDB 1huq Chain A

Receptor sequence
>1huqA (length=164) Species: 10090 (Mus musculus) [Search protein sequence]
ICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDT
TVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKE
LQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTA
MNVNEIFMAIAKKL
3D structure
PDB1huq Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S35 T53 S17 T35
BS02 GNP A S30 A31 V32 G33 K34 S35 S36 F46 E48 Q50 S52 T53 G79 N134 K135 D137 L138 S164 A165 K166 S12 A13 V14 G15 K16 S17 S18 F28 E30 Q32 S34 T35 G61 N116 K117 D119 L120 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:1huq, PDBe:1huq, PDBj:1huq
PDBsum1huq
PubMed11278565
UniProtP35278|RAB5C_MOUSE Ras-related protein Rab-5C (Gene Name=Rab5c)

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