Structure of PDB 1htt Chain A

Receptor sequence
>1httA (length=366) Species: 562 (Escherichia coli) [Search protein sequence]
NIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFK
RAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQ
RLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWR
ALGISEHVTLELNSIGSLEARANYLDEESREHFAGLCKLLESAGIAYTVN
QRLVRGLDYYNRTVFEWVTNQGTVCAGGRYDGLVEQLGGRATPAVGFAMG
LERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGV
KLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQT
AVAQDSVAAHLRTLLG
3D structure
PDB1htt Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS A T85 E131 Y264 T82 E128 Y210
BS02 AMP A R113 G120 R121 Y122 F125 Q127 R259 T281 G308 R311 R110 G117 R118 Y119 F122 Q124 R205 T223 G250 R253
Gene Ontology
Molecular Function
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006412 translation
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1htt, PDBe:1htt, PDBj:1htt
PDBsum1htt
PubMed7556055
UniProtP60906|SYH_ECOLI Histidine--tRNA ligase (Gene Name=hisS)

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