Structure of PDB 1hqt Chain A

Receptor sequence
>1hqtA (length=324) Species: 9823 (Sus scrofa) [Search protein sequence]
AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFG
NELEIGEALQETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLAD
LQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALV
AKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQ
ARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYNRSPAQILLR
WQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIVP
MLTVDGKRVPRDAGHPLYPFNDPY
3D structure
PDB1hqt The Crystal Structure of an Aldehyde Reductase Y50F Mutant-NADP Complex and its Implications for Substrate Binding
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D45 F50 K80 H113
Catalytic site (residue number reindexed from 1) D44 F49 K79 H112
Enzyme Commision number 1.1.1.19: glucuronate reductase.
1.1.1.2: alcohol dehydrogenase (NADP(+)).
1.1.1.20: glucuronolactone reductase.
1.1.1.372: D/L-glyceraldehyde reductase.
1.1.1.54: allyl-alcohol dehydrogenase.
1.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G20 T21 W22 D45 F50 K80 H113 S162 Q184 Y210 S211 P212 L213 S215 S216 A246 I261 K263 S264 V265 T266 R269 N273 G19 T20 W21 D44 F49 K79 H112 S161 Q183 Y209 S210 P211 L212 S214 S215 A245 I260 K262 S263 V264 T265 R268 N272
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047939 L-glucuronate reductase activity
GO:0047941 glucuronolactone reductase activity
GO:0047956 glycerol dehydrogenase (NADP+) activity
GO:0160163 S-nitrosoglutathione reductase (NADPH) activity
GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity
Biological Process
GO:0006629 lipid metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0046185 aldehyde catabolic process
GO:0110095 cellular detoxification of aldehyde
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1hqt, PDBe:1hqt, PDBj:1hqt
PDBsum1hqt
PubMed11306083
UniProtP50578|AK1A1_PIG Aldo-keto reductase family 1 member A1 (Gene Name=AKR1A1)

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