Structure of PDB 1hoz Chain A

Receptor sequence
>1hozA (length=316) Species: 5699 (Trypanosoma vivax) [Search protein sequence]
GSAKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNV
TGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIP
ENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDK
YGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFG
CPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMYYAWD
ALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNP
EAEFFLDMLLRSARAC
3D structure
PDB1hoz Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D10 D15 D40 W83 T137 W185 N186 W260 D261
Catalytic site (residue number reindexed from 1) D11 D16 D41 W84 T138 W186 N187 W249 D250
Enzyme Commision number 3.2.2.1: purine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D10 D15 T137 D261 D11 D16 T138 D250
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1hoz, PDBe:1hoz, PDBj:1hoz
PDBsum1hoz
PubMed11292348
UniProtQ9GPQ4

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