Structure of PDB 1hl3 Chain A

Receptor sequence
>1hl3A (length=331) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALM
YHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASV
EETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGE
TLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQD
LLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKAL
AQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI
EMREEAAREIRRAITGRIPDSLKNCVNKDHL
3D structure
PDB1hl3 Ctbp/Bars: A Dual-Function Protein Involved in Transcription Co-Repression and Golgi Membrane Fission
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S113 R255 D279 E284 H304
Catalytic site (residue number reindexed from 1) S99 R241 D265 E270 H290
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M31 V40 A41 F42 C43 E50 H52 E53 L345 M17 V26 A27 F28 C29 E36 H38 E39 L331
BS02 NAD A T117 G172 R173 V174 D193 Y195 H225 C226 G227 N232 T253 A254 R255 D279 H304 T103 G158 R159 V160 D179 Y181 H211 C212 G213 N218 T239 A240 R241 D265 H290
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:1hl3, PDBe:1hl3, PDBj:1hl3
PDBsum1hl3
PubMed12805226
UniProtQ9Z2F5|CTBP1_RAT C-terminal-binding protein 1 (Gene Name=Ctbp1)

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