Structure of PDB 1hku Chain A

Receptor sequence
>1hkuA (length=331) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALM
YHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASV
EETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGE
TLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQD
LLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKAL
AQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI
EMREEAAREIRRAITGRIPDSLKNCVNKDHL
3D structure
PDB1hku Ctbp/Bars: A Dual-Function Protein Involved in Transcription Co-Repression and Golgi Membrane Fission
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S113 R255 D279 E284 H304
Catalytic site (residue number reindexed from 1) S99 R241 D265 E270 H290
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A S89 T117 G170 G172 R173 V174 Y192 D193 P194 Y195 C226 N232 T253 A254 R255 H304 W307 L345 S75 T103 G156 G158 R159 V160 Y178 D179 P180 Y181 C212 N218 T239 A240 R241 H290 W293 L331 MOAD: ic50~65nM
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:1hku, PDBe:1hku, PDBj:1hku
PDBsum1hku
PubMed12805226
UniProtQ9Z2F5|CTBP1_RAT C-terminal-binding protein 1 (Gene Name=Ctbp1)

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