Structure of PDB 1he3 Chain A

Receptor sequence

>1he3A (length=204) Species: 9606 (Homo sapiens)

AVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVV
VGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAH
GVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMP
PHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYP
SHQY

3D structure

• PDB: 1he3 Structure of Human Biliverdin Ix Beta Reductase, an Early Fetal Bilirubin Ix Producing Enzyme
• Chain: A
• Resolution: 1.4 Å

Enzymatic activity

• Enzyme Commision number: 1.3.1.-
  1.5.1.30: flavin reductase (NADPH).
  2.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G10 T12 G13 Q14 T15 R35 R39 D54 V55 L75 G76 R78 C109 T110 S111 H132 P151 P152 H153 I154	G9 T11 G12 Q13 T14 R34 R38 D53 V54 L74 G75 R77 C108 T109 S110 H131 P150 P151 H152 I153
BS02	MBV	A	T77 R78 N79 L81 F113 W116 R124 L125 P152 H153 R174	T76 R77 N78 L80 F112 W115 R123 L124 P151 H152 R173

Gene Ontology

Molecular Function

• GO:0004074 biliverdin reductase [NAD(P)+] activity
• GO:0005515 protein binding
• GO:0008752 FMN reductase (NAD(P)H) activity
• GO:0016491 oxidoreductase activity
• GO:0016740 transferase activity
• GO:0035605 peptidyl-cysteine S-nitrosylase activity
• GO:0042602 riboflavin reductase (NADPH) activity
• GO:0052873 FMN reductase (NADPH) activity
• GO:0052874 FMN reductase (NADH) activity

Biological Process

• GO:0030219 megakaryocyte differentiation
• GO:0042167 heme catabolic process
• GO:0046627 negative regulation of insulin receptor signaling pathway

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0043231 intracellular membrane-bounded organelle
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:1he3, PDBe:1he3, PDBj:1he3
• PDBsum: 1he3
• PubMed: 11224564
• UniProt: P30043|BLVRB_HUMAN Flavin reductase (NADPH) (Gene Name=BLVRB)