Structure of PDB 1hdh Chain A

Receptor sequence

>1hdhA (length=525) Species: 287 (Pseudomonas aeruginosa)

KRPNFLVIVADDLGFSDIGAFGGEIATPNLDALAIAGLRLTDFHTASTCS
PTRSMLLTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLR
EAGYQTLMAGKWHLGLKPEQTPHARGFERSFSLLPGAANHYGFEPPYDES
TPRILKGTPALYVEDERYLDTLPEGFYSSDAFGDKLLQYLKERDQSRPFF
AYLPFSAPHWPLQAPREIVEKYRGRYDAGPEALRQERLARLKELGLVEAD
VEAHPVLALTREWEALEDEERAKSARAMEVYAAMVERMDWNIGRVVDYLR
RQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLGFLDRHYDNSLENIGR
ANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISH
AFATVMDVTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAAH
DENTVTGWELFGMRAIRQGDWKAVYLPAPVGPATWQLYDLARDPGEIHDL
ADSQPGKLAELIEHWKRYVSETGVV

3D structure

• PDB: 1hdh 1.3 A Structure of Arylsulfatase from Pseudomonas Aeruginosa Establishes the Catalytic Mechanism of Sulfate Ester Cleavage in the Sulfatase Family.
• Chain: A
• Resolution: 1.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D13 D14 C51 R55 K113 H115 A139 H211 D317 N318 K375
• Catalytic site (residue number reindexed from 1): D11 D12 C49 R53 K111 H113 A137 H209 D315 N316 K373
• Enzyme Commision number: 3.1.6.1: arylsulfatase (type I).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D13 D14 X51 D317 N318	D11 D12 X49 D315 N316
BS02	SO4	A	D14 X51 H211 K375	D12 X49 H209 K373
BS03	SO4	A	H452 T456	H450 T454

Gene Ontology

Molecular Function

• GO:0004065 arylsulfatase activity
• GO:0008081 phosphoric diester hydrolase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1hdh, PDBe:1hdh, PDBj:1hdh
• PDBsum: 1hdh
• PubMed: 11435113
• UniProt: P51691|ARS_PSEAE Arylsulfatase (Gene Name=atsA)