Structure of PDB 1hdc Chain A

Receptor sequence
>1hdcA (length=253) Species: 1905 (Streptomyces exfoliatus) [Search protein sequence]
NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELG
DAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESV
ERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSS
YGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGN
YPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYV
MGQ
3D structure
PDB1hdc Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 S139 Y152 K156
Catalytic site (residue number reindexed from 1) G16 S138 Y151 K155
Enzyme Commision number 1.1.1.53: 3alpha(or 20beta)-hydroxysteroid dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CBO A S91 T92 G93 L148 Y152 M184 M189 T190 T193 S90 T91 G92 L147 Y151 M183 M188 T189 T192 MOAD: Ki=1uM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1hdc, PDBe:1hdc, PDBj:1hdc
PDBsum1hdc
PubMed7866748
UniProtP19992|HSD_STREX 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

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