Structure of PDB 1h94 Chain A

Receptor sequence

>1h94A (length=485) Species: 1245 (Leuconostoc mesenteroides)

VSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALN
DDEFKQLVRDSIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIE
EAADKFDIDGNRIFYMSVAPRFFGTIAKYLKSEGLLADTGYNRLMIEKPF
GTSYDTAAELQNDLENAFDDNQLFRIDHYLGKEMVQNIAALRFGNPIFDA
AWNKDYIKNVQVTLCEVLGVEERAGYYDTAGALLDMIQNHTMQIVGWLAM
EKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKPY
LEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIV
FKAGTFNFGSEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLG
WTVSDEDKKNTPEPYERMIHDTMNGDGSNFADWNGVSIAWKFVDAISAVY
TADKAPLETYKSGSMGPEASDKLLAANGDAWVFKG

3D structure

• PDB: 1h94 Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D177 H178 H240
• Catalytic site (residue number reindexed from 1): D177 H178 H240
• Enzyme Commision number: 1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)(+)].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G12 T14 G15 D16 L17 A45 R46 V86 S117 E147 K148 R223	G12 T14 G15 D16 L17 A45 R46 V86 S117 E147 K148 R223

Gene Ontology

Molecular Function

• GO:0004345 glucose-6-phosphate dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050661 NADP binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006098 pentose-phosphate shunt
• GO:0009051 pentose-phosphate shunt, oxidative branch

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1h94, PDBe:1h94, PDBj:1h94
• PDBsum: 1h94
• PubMed: 11320304
• UniProt: P11411|G6PD_LEUME Glucose-6-phosphate 1-dehydrogenase (Gene Name=zwf)