Structure of PDB 1h8y Chain A

Receptor sequence
>1h8yA (length=247) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTF
KIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPV
FQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEF
LESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGV
AWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
3D structure
PDB1h8y Crystal Structures of the Class D B-Lactamase Oxa-13 in the Native Form and in Complex with Meropenem
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S67 K70 S115 F120 W154 F208
Catalytic site (residue number reindexed from 1) S48 K51 S96 F101 W135 F189
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MER A S67 T206 G207 F208 L247 R250 S48 T187 G188 F189 L228 R231 PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization

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Molecular Function
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Biological Process
External links
PDB RCSB:1h8y, PDBe:1h8y, PDBj:1h8y
PDBsum1h8y
PubMed11453693
UniProtQ51400

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