Structure of PDB 1h7b Chain A

Receptor sequence
>1h7bA (length=534) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
DSRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHESGIIHVHDIDYSPALP
FTNCCLVDLKGMLENGFKLGNAQIETPKSIGVATAIMAQITAQVASHQYG
GTTFANVDKVLSPYVKRTYAKHIEDAEKWQIADALNYAQSKTEKDVYDAF
QAYEYEVNTLFSSNGQTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRD
GITPIFPKLVMFVEEGVNLYKDDPNYDIKQLALECASKRMYPDIISAKNN
KAITGSSVPVSPMGCRSFLSVWKDSTGNEILDGRNNLGVVTLNLPRIALD
SYIGTQFNEQKFVELFNERMDLCFEALMCRISSLKGVKATVAPILYQEGA
FGVRLKPDDDIIELFKNGRSSVSLGYIGIHELNILVGRDIGREILTKMNA
HLKQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDVTDKGWYTNS
FHVSVEENITPFEKISREAPYHFIATGGHISYVELPDMKNNLKGLEAVWD
YAAQHLDYFGVNMPVDKCMNTIRRTCAYLGNPNE
3D structure
PDB1h7b Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N78 C79 M288 C290 S292 N311 Y441 E446 A580
Catalytic site (residue number reindexed from 1) N53 C54 M263 C265 S267 N286 Y416 E421 A527
Enzyme Commision number 1.1.98.6: ribonucleoside-triphosphate reductase (formate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A H66 A445 N447 L448 H41 A420 N422 L423
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h7b, PDBe:1h7b, PDBj:1h7b
PDBsum1h7b
PubMed11587648
UniProtP07071|NRDD_BPT4 Anaerobic ribonucleoside-triphosphate reductase (Gene Name=nrdD)

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