Structure of PDB 1h7a Chain A

Receptor sequence
>1h7aA (length=563) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
SRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHESGIIHVHDIDYSPALPF
TNCCLVDLKGMLENGFKLGNAQIETPKSIGVATAIMAQITAQVASHQYGG
TTFANVDKVLSPYVKRTYAKHIEDAEKWQIADALNYAQSKTEKDVYDAFQ
AYEYEVNTLFSSNGQTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRDG
ITPIFPKLVMFVEEGVNLYKDDPNYDIKQLALECASKRMYPDIISAKNNK
AITGSSVPVSPMGCRSFLSVWKDSTGNEILDGRNNLGVVTLNLPRIALDS
YIGTQFNEQKFVELFNERMDLCFEALMCRISSLKGVKATVAPILYQEGAF
GVRLKPDDDIIELFKNGRSSVSLGYIGIHELNILVGRDIGREILTKMNAH
LKQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDVTDKGWYTNSF
HVSVEENITPFEKISREAPYHFIATGGHISYVELPDMKNNLKGLEAVWDY
AAQHLDYFGVNMPVDKCFTCGSTHEMTPTENGFVCSICGETDPKKMNTIR
RTCAYLGNPNERG
3D structure
PDB1h7a Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N78 C79 M288 C290 S292 N311 Y441 E446 A580
Catalytic site (residue number reindexed from 1) N52 C53 M262 C264 S266 N285 Y415 E420 A554
Enzyme Commision number 1.1.98.6: ribonucleoside-triphosphate reductase (formate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP A I99 E100 K103 V107 I111 Q114 K146 I73 E74 K77 V81 I85 Q88 K120 PDBbind-CN: -logKd/Ki=4.72,Kd=19uM
BS02 FE2 A C543 C546 C561 C564 C517 C520 C535 C538
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

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Cellular Component
External links
PDB RCSB:1h7a, PDBe:1h7a, PDBj:1h7a
PDBsum1h7a
PubMed11587648
UniProtP07071|NRDD_BPT4 Anaerobic ribonucleoside-triphosphate reductase (Gene Name=nrdD)

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