Structure of PDB 1h78 Chain A

Receptor sequence
>1h78A (length=534) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
DSRVFPTQRDLMAGIVSKHIAKNMVPSFIMKAHESGIIHVHDIDYSPALP
FTNCCLVDLKGMLENGFKLGNAQIETPKSIGVATAIMAQITAQVASHQYG
GTTFANVDKVLSPYVKRTYAKHIEDAEKWQIADALNYAQSKTEKDVYDAF
QAYEYEVNTLFSSNTPFVTITFGTGTDWTERMIQKAILKNRIKGLGRDGI
TPIFPKLVMFVEEGVNLYKDDPNYDIKQLALECASKRMYPDIISAKNNKA
ITGSSVPVSPMGCRSFLSVWKDSTGNEILDGRNNLGVVTLNLPRIALDSY
IGTQFNEQKFVELFNERMDLCFEALMCRISSLKGVKATVAPILYQEGAFG
VRLKPDDDIIELFKNGRSSVSLGYIGIHELNILVGRDIGREILTKMNAHL
KQWTERTGFAFSLYSTPAENLCYRFCKLDTEKYGSVKDVTDKGWYTNSFH
VSVEENITPFEKISREAPYHFIATGGHISYVELPDMKNNLKGLEAVWDYA
AQHLDYFGVNMPVDKCFTMNTIRRTCAYLGNPNE
3D structure
PDB1h78 Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N78 C79 M288 C290 S292 N311 Y441 E446 A580
Catalytic site (residue number reindexed from 1) N53 C54 M261 C263 S265 N284 Y414 E419 A527
Enzyme Commision number 1.1.98.6: ribonucleoside-triphosphate reductase (formate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCP A H64 H66 D67 P444 A445 E446 N447 R451 H39 H41 D42 P417 A418 E419 N420 R424
BS02 DCP A I99 E100 K103 V107 I111 Q114 K146 I74 E75 K78 V82 I86 Q89 K121
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

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Cellular Component
External links
PDB RCSB:1h78, PDBe:1h78, PDBj:1h78
PDBsum1h78
PubMed11587648
UniProtP07071|NRDD_BPT4 Anaerobic ribonucleoside-triphosphate reductase (Gene Name=nrdD)

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