Structure of PDB 1h70 Chain A

Receptor sequence
>1h70A (length=255) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
FMFKHIIARTPARSLVDGLTSSHLGKPDYAKALEQHNAYIRALQTCDVDI
TLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRF
YPGKVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHG
LSGSVVRLEKVLHLKTGLAYLEHNNLLAAGEFVSKPEFQDFNIIEIPEEE
SYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSS
MSLRF
3D structure
PDB1h70 Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.3.18: dimethylargininase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CIR A L18 D60 F63 E65 D66 R85 R132 H162 I243 D244 S249 L19 D61 F64 E66 D67 R86 R133 H163 I244 D245 S250
Gene Ontology
Molecular Function
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000052 citrulline metabolic process
GO:0006525 arginine metabolic process
GO:0045429 positive regulation of nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1h70, PDBe:1h70, PDBj:1h70
PDBsum1h70
PubMed11473257
UniProtQ9I4E3|DDAH_PSEAE N(G),N(G)-dimethylarginine dimethylaminohydrolase (Gene Name=PA1195)

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