Structure of PDB 1h6h Chain A

Receptor sequence
>1h6hA (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
AVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGS
KYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEI
AEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVP
3D structure
PDB1h6h The Crystal Structure of the Px Domain from P40Phox Bound to Phosphatidylinositol 3-Phosphate
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIB A R58 Y59 R60 K92 V93 Y94 R105 R57 Y58 R59 K91 V92 Y93 R104 MOAD: Kd=5uM
PDBbind-CN: -logKd/Ki=5.30,Kd=5.0uM
Gene Ontology
Molecular Function
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006909 phagocytosis
GO:0045730 respiratory burst
Cellular Component
GO:0043020 NADPH oxidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h6h, PDBe:1h6h, PDBj:1h6h
PDBsum1h6h
PubMed11684018
UniProtQ15080|NCF4_HUMAN Neutrophil cytosol factor 4 (Gene Name=NCF4)

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