Structure of PDB 1h5y Chain A

Receptor sequence
>1h5yA (length=252) Species: 13773 (Pyrobaculum aerophilum) [Search protein sequence]
HMALRIIPCLDIDGGAKVVVKGVNFQGIREVGDPVEMAVRYEEEGADEIA
ILDITAAPEGRATFIDSVKRVAEAVSIPVLVGGGVRSLEDATTLFRAGAD
KVSVNTAAVRNPQLVALLAREFGSQSTVVAIDAKWNGEYYEVYVKGGREA
TGLDAVKWAKEVEELGAGEILLTSIDRDGTGLGYDVELIRRVADSVRIPV
IASGGAGRVEHFYEAAAAGADAVLAASLFHFRVLSIAQVKRYLKERGVEV
RI
3D structure
PDB1h5y Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D12 D133
Catalytic site (residue number reindexed from 1) D11 D132
Enzyme Commision number 4.3.2.10: imidazole glycerol-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A G85 N106 T107 G84 N105 T106
BS02 PO4 A D179 G180 A226 A227 S228 D178 G179 A225 A226 S227
BS03 GOL A N106 A131 D133 N105 A130 D132
BS04 GOL A K22 G147 D179 K21 G146 D178
Gene Ontology
Molecular Function
GO:0000107 imidazoleglycerol-phosphate synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h5y, PDBe:1h5y, PDBj:1h5y
PDBsum1h5y
PubMed11679715
UniProtQ8ZY16|HIS6_PYRAE Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)

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