Structure of PDB 1h4w Chain A

Receptor sequence
>1h4wA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRL
GEHNIKVLEGNEQFINAVKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKA
SYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
3D structure
PDB1h4w Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 R193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 R175 D176 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEN A D189 S190 C191 Q192 S195 G219 D171 S172 C173 Q174 S177 G196 MOAD: Ki=22uM
PDBbind-CN: -logKd/Ki=4.66,Ki=22uM
BS02 CA A E70 N72 V75 E77 E80 E52 N54 V57 E59 E62
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1h4w, PDBe:1h4w, PDBj:1h4w
PDBsum1h4w
PubMed11827488
UniProtP35030|TRY3_HUMAN Trypsin-3 (Gene Name=PRSS3)

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