Structure of PDB 1gzf Chain A

Receptor sequence
>1gzfA (length=203) Species: 1491 (Clostridium botulinum) [Search protein sequence]
TYQEFTNIDQAKAWGNAQYKKYGLSKSEKEAIVSYTKSASEINGKLRQNK
GVINGFPSNLIKQVELLDKSFNKMKTPENIMLFRGDDPAYLGTEFQNTLL
NSNGTINKTAFEKAKAKFLNKDRLEYGYISTSLMNVSQFAGRPIITKFKV
AKGSKAGYIDPISAFAGQLEMLLPRHSTYHIDDMRLSSDGKQIIITATMM
GTA
3D structure
PDB1gzf Nad Binding Induces Conformational Changes in Rho Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S174 E214
Catalytic site (residue number reindexed from 1) S130 E170
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A T80 N87 R91 R128 G129 D130 D131 A133 R167 E169 T175 S176 F183 R186 Q212 E214 T36 N43 R47 R84 G85 D86 D87 A89 R123 E125 T131 S132 F139 R142 Q168 E170 MOAD: Kd=60uM
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:1990404 NAD+-protein ADP-ribosyltransferase activity
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1gzf, PDBe:1gzf, PDBj:1gzf
PDBsum1gzf
PubMed12029083
UniProtP15879|ARC3_CBDP Mono-ADP-ribosyltransferase C3 (Gene Name=C3)

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