Structure of PDB 1gwq Chain A

Receptor sequence
>1gwqA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKNSLALSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA
QLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR
3D structure
PDB1gwq Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 D538 L539 E542 M543 I53 K57 L67 D233 L234 E237 M238
BS02 ZTW A E353 L387 F404 M421 H524 L525 E48 L82 F99 M116 H219 L220 BindingDB: EC50=1400nM,IC50=1410nM,Ki=4.1nM
External links
PDB RCSB:1gwq, PDBe:1gwq, PDBj:1gwq
PDBsum1gwq
PubMed11937504
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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