Structure of PDB 1gwi Chain A

Receptor sequence
>1gwiA (length=402) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
ARIPLDPFVTDLDGESARLRAAGPLAAVELPGGVPVWAVTHHAEAKALLT
DPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHRRLRTLV
AQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKAAFAYPLPMYVVA
DLMGIEEARLPRLKVLFEKFFSTQTPPEEVVATLTELASIMTDTVAAKRA
APGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVN
LSTHPEQRALVLSGEAEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRV
IPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGNRHISFGHGPHVCPG
AALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVTQNDLFELPVRLA
HH
3D structure
PDB1gwi The 1.92 A Structure of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase that Functionalizes Macrolide Ring Systems
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S179 A242 E245 T246 T247 T289 C355 P356 G357 E364 Q396
Catalytic site (residue number reindexed from 1) S172 A235 E238 T239 T240 T282 C348 P349 G350 E357 Q389
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M92 H100 R104 L238 A242 G243 T246 V292 R295 Y318 S347 F348 H353 C355 P356 G357 S361 M85 H93 R97 L231 A235 G236 T239 V285 R288 Y311 S340 F341 H346 C348 P349 G350 S354
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1gwi, PDBe:1gwi, PDBj:1gwi
PDBsum1gwi
PubMed12519772
UniProtQ9L142

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